If you find the game crashing before opening to the main screen you can go to:
%localappdata%
Search for Wolverine_Studios and delete that folder, or the folders within (You may see a pro and/or college folder). That is the folder where the user settings are stored for the game. Deleting the files causes them to be rebuilt so it will not affect any of your leagues. In some cases these settings files can be corrupted by windows during a save... deleting them fixes the issue.
Thanks so much to those who helped me debug this issue!