Is there somewhere that explains on how to set up depth charts?

If there is, I don't know about it. Do you have specific questions?

Generally, depth charts are pretty self explanatory.

You can create different depth charts, giving them each a name, then you can weight each depth chart to be used in different situations. So 3rd and long you can have your blocking back in with your speedy receivers on offense, or your pass rushers, blitzers, and/or coverage linebackers on defense. You do this by weighting them in each situation, so zero means that depth chart won't be used.

Don't know if any of this answers any questions in your mind, but if it doesn't or you have more specific questions, there are many people here that can probably help you.

Weighting them? I don't see anyway to weight anyone except tier them. Thank you for responding.

If you go to strategy and then click "formations" in the top menu, you can assign weights to your packages.