Just got the game and trying to autosimulate the first season. Right away I get this. I have deleted and created several leagues and get this every time.

An unhandled exception occurred: Could not use [path]\working.pbb. file already in use.
The game will now exit.

Do you happen to have OneDrive automatically backing up your My Documents folder? If so set the Wolverine Studios as an exemption to not be automatically backed up.

No but I do have Google drive backing up that directory. I added an exception for the .pbb file and that seems to have worked. Thanks.