Just had a bug while using 'Sim Week' where a CPU team had a major injury (torn ACL) to a player in their starting lineup and for some reason I guess the game didn't auto-adjust their lineup, so the game became stuck and every time I would hit 'play/sim game' to advance the day, I would get a message saying something like "Invalid Roster Setting - Penn State has a player in their starting lineup that is too injured to play'. I was able to fix this by switching to commissioner and fixing it manually but just wanted to let you know since it's the first time I've seen that happen.
I should point out, in case it matters, that I was not on the updated build when this happened. Was on the original build, got the bug, tried updating, and it didn't fix it (wasn't expecting it to though).